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adenine nucleotide translocase symport

adenine nucleotide translocase symport

of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.

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A UniProt proteome can consist of several components.

The component name refers to the genomic component encoding a set of proteins.

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This section provides information on the location and the topology of the mature protein in the cell.

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This subsection of the 'Subcellular location' section describes the extent of a membrane-spanning region of the protein. We'd like to inform you that we have updated our Privacy Notice to comply Conjugate: Unconjugated. Adenine nucleotide translocase (ANT) was found to be the only protein in the mitochondrial membranes exhibiting a detectable age-associated increase in carbonyls. using the generator polynomial: x64 + x4 + x3 + x + 1. The Molecular and Physiological Effects of Protein-Derived Polyamines in the Intestine.

This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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Sequence statusi: Complete. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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Information which has been generated by the UniProtKB automatic annotation system, without manual validation.

from the sequence. Furthermore, all channel proteins are the examples of uniports, and Na/glucose symporter is an example of a symport… It facilitates exchange of ADP and ATP between the cytosol and … with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018. Here, we show that Bcl-2 enhances the ADP/ATP exchange in proteoliposomes containing the purified adenine nucleotide translocase (ANT) in isolated mitochondria and mitoplasts, as well as in … Adenine nucleotide translocase Imported Submitted name: Slc25a5-prov protein Imported. Tested Reactivity: Human, Mouse, Rat. See also. Importantly, ANT1 mRNA levels are increased in human and mouse cell lines devoid of MeCP2, in Rett syndrome (312750) patient fibroblast, and in the brain of MeCP2-null mice. Uptake of spermine by rat liver mitochondria and its influence on the transport of phosphate. Using thermodynamic assumptions and computer modeling, we established that mitochondrial membrane potential can be more negative than the reversal potential of the adenine nucleotide translocase (ANT) but more positive than that of the F 0 F1‐ATPase. The second one takes place in energizing conditions during the activity of the adenine nucleotide translocase and is mediated by an electroneutral symport mechanism involving the efflux in co-transport of spermine and phosphate and the exchange of exogenous ADP with endogenous ATP. (2018) reported that the FAM173A gene encodes a 235-amino acid protein. These are stable identifiers and should be used to cite UniProtKB entries. Rabbit Polyclonal Anti-Adenine Nucleotide Translocator 2 Antibody. Here, we show that equivalent mutations in …  |  Phosphate translocase is also located in the inner mitochondrial membrane. Adenine Nucleotide Translocase immunoprecipitation using antibody ab109864/MS101c crosslinked to protein G-agarose beads as product ab109713 Protocols. The first one is induced in deenergizing conditions by FCCP or antimycin A and it is mediated by an electroneutral exchange spermine protons. Reactivity: Hu Species Glossary: Applications: ELISA, S-ELISA: Clone: 1D7. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.

NIH  |  Draws On The ApH C. Has No Energy Cost D. Spans The … (2010) further … At 0.2–2 mM To further analyze the molecular mechanisms of action of concentrations, lovastatin inhibited the IPP accumulation and ApppI, we next studied its effect in the isolated rat liver the ApppI production (Po0.001) in a dose dependent manner … ANT1 is a 298 amino acid ~:32kDA multi-pass inner mitochondrial memebrane transmembrane glycoprotein. The algorithm is described in the ISO 3309 standard. Adenine nucleotide translocases (ANTs) are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in cytosol. The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the inner mitochondrial membrane, transports ADP and ATP across the membrane.

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2016 Oct;48(10):2313-26. doi: 10.1007/s00726-016-2323-z. FEBS Lett. Adenine Nucleotide … Missense mutations in the Ant1 isoform cause autosomal dominant Progressive External Ophthalmoplegia (adPEO), cardiomyopathy and myopathy. The ANTKMT gene encodes a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase (ANT) and affects mitochondrial respiration (Malecki et al., 2019). USA.gov. Protein sets from fully sequenced genomes.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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Information which has been imported from another database using automatic procedures.

Here, we describe the isolation of adenine nucleotide translocase-1 (ANT-1) in a screen for dominant, apoptosis-inducing genes. ANT-1 is a component of the mitochondrial permeability transition complex, a protein aggregate connecting the inner with the outer mitochondrial membrane that has recently been implicated in apoptosis. This paper briefly overviews experimental results focusing on the role of ANT in the mitochondrial permeability transition and The adenine nucleotide translocase (ADP-ATP translocase), a transporter located in the innter mitochondrial membrane, transports ADP and ATP across the membrane. Milestones and recent discoveries on cell death mediated by mitochondria and their interactions with biologically active amines. (1999) J. Synonyms: Ant1 Imported, slc25a5 Imported. The recognition of two specific binding sites of the adenine nucleotide translocase by palmitoyl CoA in bovine heart mitochondria and submitochondrial particles. HHS 618566 - adenine nucleotide translocase lysine methyltransferase; antkmt - family with sequence similarity 173, member a; fam173a;; chromosome 16 open reading frame 24; c16orf24 - antkmt

It should be noted that while, in theory, two different sequences could Order Details 100% Guarantee on every product. 2014 Mar;46(3):671-9. doi: 10.1007/s00726-013-1591-0. Cell Biol. Ohkubo S, Mancinelli R, Miglietta S, Cona A, Angelini R, Canettieri G, Spandidos DA, Gaudio E, Agostinelli E. Int J Oncol. ADP/ATP translocase, the most abundant mitochondrial protein, is an integral component of the inner mitochondrial membrane. was revealed by studying some mutant forms of adenine nucleotide translocase, which causes aging-dependent cellu-lar degeneration. ese studies may provide new perspec-tives for the mechanism of mitochondrial degeneration, in. (2010) showed that MeCP2 (300005) cooperates with YY1 (600013) in repressing the ANT1 gene, encoding a mitochondrial adenine nucleotide translocase. 13-1 for the ionic forms of ATP and ADP). Here, we describe the characterization of adenine nucleotide translocase-1 (ANT-1), a central component of the permeability transition pore, which was identified using such a screen. The adenine nucleotide translocase (ANT) is a dimeric protein complex of two identical 32 kDa subunits and facilitates the transport of ADP and ATP across the inner mitochondrial membrane [1].

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